沙奎那韋脂質(zhì)體、殼聚糖多功能納米粒子
西安齊岳生物科技有限公司是國(guó)內(nèi)的納米晶體生產(chǎn)制造商，我們提供定制合成多種光電材料，供應(yīng)多孔有機(jī)框架POF，納米晶體；發(fā)光導(dǎo)電納米晶體；殼聚糖基多功能納米晶體；環(huán)糊精復(fù)合納米粒子；血漿蛋白-脂溶性納米晶體；介孔二氧化硅包覆金納米顆粒；核苷酸納米脂質(zhì)體劑
Fe_3O_4/奧曲肽修飾的雙靶向納米脂質(zhì)體；美洛昔康納米晶體；凍融納米晶體的脂質(zhì)體；熒光CdSe復(fù)合脂質(zhì)體；洛伐他汀納米脂質(zhì)體；多西紫杉醇靶向納米
沙奎那韋脂質(zhì)體、殼聚糖多功能納米粒子
殼聚糖基多功能納米載體系統(tǒng), 并探討了其體外釋藥性質(zhì). 合成了甲氨蝶呤-殼聚糖偶聯(lián)物(MTX-CS), 甲氨喋呤(MTX)的取代度為6.3%; MTX-CS具有兩親性, 在水性介質(zhì)中能自組裝形成納米粒子, 平均粒徑為(269.5±18.3) nm, zeta電位為(25.7±0.9) mV. MTX-CS納米粒子能包載抗生成藥Combretastatin A-4(CA-4), 當(dāng)載體材料投料比為1∶4 時(shí), 載藥量為15.7%, 包封率為62.8%. 體外釋放實(shí)驗(yàn)結(jié)果顯示, CA-4釋放較快, MTX釋放緩慢, 有利于發(fā)揮的協(xié)同抗作用.
The preparation method of a chitosan-based multifunctional nano-drug carrier system and its drug release properties were reported. Methotrexate conjugated chitosan(MTX-CS) was synthesized and characterized, and the substitution degree of MTX was 6.3%. MTX-CS had amphiphilic property, thus could form self-assembled nanoparticles in aqueous medium. The mean diameter of MTX-CS nanoparticles was (269.5±18.3) nm, and the zeta potential was (25.7±0.9) mV. MTX-CS nanoparticles could effectively load antitumor drugcombretastatin A-4(CA-4); CA-4 loading content and entrapment efficiency were 15.7% and 62.8%, respectively, when the feed mass ratio of drug and carrier was 1∶4. The in vitro release experiment shows that CA-4 rapidly releases from MTX-CS nanoparticles, but MTX release rate obviously slows, which is favorable for the combination tumor therapy.
西安齊岳生物科技有限公司其他產(chǎn)品：
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酰胺ⅢB納米粒子脂質(zhì)體
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槲皮素納米脂質(zhì)體
高密度脂蛋白(HDL)脂質(zhì)體
洛伐他汀納米脂質(zhì)體
內(nèi)部明膠增稠脂質(zhì)體
多西紫杉醇靶向納米
多功能聚縮酮納米粒子
溫馨提示；齊岳生物供應(yīng)產(chǎn)品用于科研；（zhn2020.0226）
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