產(chǎn)品新聞

背景資料

LDL is a low-density lipoprotein that transports cholesterol and triglycerides from the liver to peripheral tissues. LDL （like all lipoproteins） facilitates the movement of fats and cholesterol within the water based solution of the blood stream. Each natural LDL particle contains a single Apo B-100 molecule （apolipoprotein B-100 is a protein with 4536 amino acid residues） that circulates the fatty acids and keeps them soluble in the aqueous environment. Additionally， the LDL core is highly-hydrophobic， consisting of linoleate （a polyunsaturated fatty acid） and about 1500 esterified cholesterol molecules. This core is enclosed by a shell of phospholipids and unesterified cholesterol in addition to a single copy of B-100 large protein （514 kD）. Even though the LDL particles are approximately 22 nm in diameter and have a mass of about 3 million Daltons， they have a mass and size distribution since the LDL particles contain a varying number of fatty acids. LDL receptors are synthesized and placed in the plasma membrane when a cell requires cholesterol. The LDL receptors scatter freely until they link to clathrin-coated pits. LDL particles in the blood stream attach to these extracellular LDL receptors. The clathrin-coated pits at that time form vesicles that are endocytosed into the cell. Once the clathrin coat is dropped， the vesicles transport the LDL and their receptors to early endosomes， onto late endosomes to lysosomes. At this point the cholesterol esters in the LDL are hydrolysed. The LDL receptors are recovered back to the plasma membrane. Since LDLs convey cholesterol to the arteries and can be retained there by arterial proteoglycans initializing the formation of plaques， increased levels are linked to atherosclerosis， and thus heart attack， stroke， and peripheral vascular disease. And so， cholesterol within LDL lipoproteins is habitually called "bad" cholesterol. This is a misconception since the cholesterol transported on LDL is the same as the one transported on other lipoprotein particles， it is in itself not "bad"， rather it is how and where the cholesterol is being transported， and in what amounts ultimately， which causes adverse effects. HDL / LDL ratio can give an indication of risk for arteriosclerosis.

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來源宿主

人血漿中提取純化

溶解建議

Yellow to orange liquid.

保存建議

Human LDL although stable at 4℃ for 1 week， should be stored desiccated below -15℃. （short term i.e. < 3 months） and below -70℃ for long term.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細(xì)胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。  的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽，這就對工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。