背景資料

Gangliosides are formed from a glycosphingolipid combined with one or more sialic acids at the oligosaccharide chain. They are anchored at the outer surface of the plasma membrane where they pack densely with cholesterol to form lipid microdomains that modulate both intra- and inter-cellular signaling events. Ganglioside GQ1b is a tetrasialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. At 5 nM, it can stimulate an ecto-type (cell-surface) protein phosphorylation system in the human neuroblastoma cell line GOTO.{25486} Ganglioside GQ1b has been reported to promote neurite outgrowth during early neuronal differentiation by activating the ERK1/2 MAP kinase pathway.{25483} It has also been shown to initiate keratinocyte differentiation through phophoinositide turnover.{25487}

產品描述

A tetrasialoganglioside that promotes neurite outgrowth during early neuronal differentiation via ERK1/2 MAP kinase pathway activaton; also initiates keratinocyte differentiation

保存建議

建議您在收到開曼生物品牌的Ganglioside GQ1b (sodium salt) (500 µg)產品后置于-20度保存，產品有效期為730天.

其他

開曼生物向全球科學工作者提供多研究領域的生化、免疫試劑和分析試劑盒，其產品被廣泛應用于腫瘤、氧化氮、神經學、凋亡、氧化性損傷、內分泌學等不同研究領域.開曼生物可提供用于檢測的特色試劑盒，如：類花生酸類物質、游離的生物標志、環核苷、激素及氧化氮等；也提供多種高質量試劑，包括：類花生酸類物質、氧化氮試劑及許多相關脂質、脂肪酸、酶和抗體.作為開曼生物在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供的開曼生物產品以及客戶訂制化服務.