背景資料

20-HETE is a major biologically active cytochrome P450 （CYP450） metabolite of arachidonic acid in the kidney and liver. It regulates renal vascular and tubular functions as well as vascular tone in the cerebral circulation. HET0016 is an inhibitor of 20-HETE formation in human renal microsomes with an IC50 of 8.9 nM， selectively inhibiting CYP4A and 4F isoforms. HET0016 inhibits CYP2C9， CYP2D6， and CYP3A4， enzymes important in drug metabolism， significantly less effectively with IC50s in the uM range. The IC50 values for inhibition of cyclooxygenase and epoxyeicosatrienoic acids （EETs） formation are 2.3 and 2.8 uM， respectively.

產品描述

20-HETE is a major biologically active CYP450 metabolite of arachidonic acid in the kidney and liver. It regulates renal vascular and tubular functions as well as vascular tone in the cerebral circulation.{12466，12470，12468，12467，9023} HET0016 is an inhibitor of 20-HETE formation in human renal microsomes with an IC50 of 8.9 nM， selectively inhibiting CYP4A and 4F isoforms.{8946，12469} HET0016 inhibits CYP2C9， CYP2D6， and CYP3A4， enzymes important in drug metabolism， significantly less effectively with IC50 values in the uM range. The IC50 values for inhibition of COX and epoxyeicosatrienoic acids （EETs） formation are 2.3 and 2.8 uM， respectively.{8946}

保存建議

建議您在收到開曼生物品牌的HET0016 （10 mg）產品后置于-20度保存，產品有效期為730天.

其他

開曼生物向全球科學工作者提供多研究領域的生化、免疫試劑和分析試劑盒，其產品被廣泛應用于腫瘤、氧化氮、神經學、凋亡、氧化性損傷、內分泌學等不同研究領域.開曼生物可提供用于檢測的特色試劑盒，如：類花生酸類物質、游離的生物標志、環核苷、激素及氧化氮等；也提供多種高質量試劑，包括：類花生酸類物質、氧化氮試劑及許多相關脂質、脂肪酸、酶和抗體.作為開曼生物在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供面的開曼生物產品以及客戶訂制化服務.