胰高血糖素樣肽2（GLP-2）是一種主要在腸道和胰腺中合成的肽激素。GLP-2結(jié)合并激活GLP-2受體，表現(xiàn)出血管擴(kuò)張，抗高血壓，抗抑郁和胃腸動(dòng)力調(diào)節(jié)活性。在動(dòng)物模型中，GLP-2增加腸道血流量并降低平均動(dòng)脈血壓。GLP-2通過(guò)涉及PKA激活的機(jī)制增強(qiáng)L型電壓門(mén)控Ca2+通道。此外，GLP-2減少了接受強(qiáng)制游泳測(cè)試的動(dòng)物的靜止時(shí)間。這種肽刺激細(xì)胞增殖，抑制化療誘導(dǎo)的腸道粘膜萎-縮。GLP-2還可以減少胃排空和胃腸蠕動(dòng)。

艾美捷LKT Labs 胰高血糖素樣肽II，大鼠 #G4485參數(shù)說(shuō)明： 

Cas No.：89750-15-2

純度：≥95%

公式：C165H254N44O55S

配方重量：3766.2

同義詞：GLP-2

儲(chǔ)存溫度：-20°C

LKT Labs 胰高血糖素樣肽II，大鼠文獻(xiàn)引用：

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Hansen LB. GLP-2 and mesenteric blood flow. Dan Med J. 2013 May;60(5):B4634. PMID: 23673268.

Rasmussen AR, Viby NE, Hare KJ, et al. The intestinotrophic peptide, GLP-2, counteracts the gastrointestinal atrophy in mice induced by the epidermal growth factor receptor inhibitor, erlotinib, and cisplatin. Dig Dis Sci. 2010 Oct;55(10):2785-96. PMID: 20112065.

Wang Y, Guan X. GLP-2 potentiates L-type Ca2+ channel activity associated with stimulated glucose uptake in hippocampal neurons. Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E156-66. PMID: 19920220.

Iwai T, Hayashi Y, Narita S, et al. Antidepressant-like effects of glucagon-like peptide-2 in mice occur via monoamine pathways. Behav Brain Res. 2009 Dec 1;204(1):235-40. PMID: 19539656.

Mojsov S, Kopczynski MG, Habener JF. Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas. J Biol Chem. 1990 May 15;265(14):8001-8. PMID: 1692320.

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