卡氏肺孢子蟲ifa熒光檢測試劑（科研）

廣州健侖生物科技有限公司

【Cellabs簡介】

Cellabs是一家位于悉尼的擁有先進生物技術的診斷公司，專門從事熱帶病和傳染病免疫診斷試劑盒的設計、開發和生產。 Cellabs成立于1985年，由免疫學家A.M.Smithyman博士創立的診斷公司，Cellabs是澳大利亞成立zui早的個人生物科技公司。到1990年，Cellabs發布了Giardia，Cryptosporidium和Chlamydia的*個商業診斷測試范圍。所有產品都在國內本地和取得不錯的響應，該公司不斷擴大其產品系列，目前在銷售了超過20種診斷試劑盒。該公司主要診斷的是被人們忽視的熱帶病，例如瘧疾、利什曼病和象皮病。其中瘧疾每30*死一個孩子，在91個國家流行，風險高達世界人口的40％，這些疾病這給人口造成了巨大的負擔。(Cellabs診斷試劑 Cellabs公司中國總代理)
 

【Cellabs產品介紹】

Cellabs專門從事熱帶和傳染病免疫診斷試劑盒的開發，制造和銷售。還還專門檢測水性寄生蟲，特別是賈第蟲和隱孢子蟲，現在是歐洲市場上這種試劑的主要供應商。其中Cellabs Crypto Cel Reagent是英國飲用水檢測中心的*抗體。Cellabs根據ISO13485在質量管理體系（QMS）下生產產品。所有產品均已在澳大利亞治療用品管理局（TGA）注冊，并根據EC指令98/79 / EC注冊。自2013年6月起，Cellabs開始制造Tropbio ELISA產品。 Al Tropbio產品在現有的Cellabs質量管理體系（QMS）下以同樣的高水平的制造工藝生產。

卡氏肺孢子蟲ifa熒光檢測試劑（科研）

PNEUMO CEL INDIRECT IF TEST

INTENDED USE
The Pneumo Cel Indirect IF Test is an invitro indirect Immunofluorescence test for the detection of Pneumocystis carinii (P.jirovecii) in human specimens.
INTRODUCTION
P.carinii(P.jirovecii) (PC) is an extracellular eukaryotic organism shown to be related to the fungi (1). It is an opportunistic pathogen causing interstitial pneumonia in 
immunosuppressed hosts, such as premature infants, children with congenital immunodeficiencies and organ transplant recipients (2,3,4). With the advent of the acquired 
immunodeficiency syndrome (AIDS), P. carini (P.jirovecii)i pneumonia (PCP) has emerged as the most common life-threatening opportunistic infection in these patients. PCP 
occurs in over 75% of AIDS patients (5,6,7) and is usually associated with diminished CD4+ cells (8).
PC is generally confined to the lungs, although there have been recent reports of disseminated extrapulmonary disease (9) which may be as a result of the common use of 
aerosolised pentamidine (10).
The most common form of PC is the thick-walled cyst (5-8mm) containing up to 8 intracystic bodies (sporozoites, 1-2mm). These mature into extracystic pleomorphic forms, 
the trophozoites (2-5mm). The development cycle occurs in both the alveolar epithelial cells and in the alveolar spaces.

PRINCIPLE OF THE TEST

PC may be identified by a variety of histochemical stains such as methenamine silver, Giemsa and toluidine blue (11). The stains can, however, be difficult to perform, they

are non-specific and they may not detect all stages of the life cycle of the organism. Experience is also required for interpretation. More recently, immunofluorescence

assays (IFA) using monoclonal antibodies to PC have been developed. These techniques are rapid, easy to perform and specimens from induced sputum and

bronchoalveolar lavage can be used, thus avoiding the need for more invasive procedures such as lung and transbronchial biopsies. IFA has been shown to be both specific

and sensitive (12,13), and also more sensitive than histochemical staining (14).

The PNEUMO-CEL INDIRECT IF TEST is an indirect immuno-fluorescence test for PC organisms in methanol-fixed specimens. The fluorescein-labelled mouse monoclonal

antibodies bind specifically to the murine raised monoclonal, initially bound to the organisms. Washing steps, following both the monoclonal and fluorescein conjugated

antibodies, removes any unbound antibody. When viewed under a fluorescence microscope, PC are seen as bright , apple green bodies which may be present singularly or

in cluster. Trophozoites, cysts and the extra cellular matrix , which binds cysts, are stained.

健侖生物有以下呼吸道檢測試劑：

基孔肯雅熱檢測試劑

利什曼原蟲檢測試劑

登革熱檢測試劑

瘧疾檢測試劑

流行性腮腺炎檢測試劑

麻疹檢測試劑

霍亂檢測試劑

萊姆病檢測試劑

水痘檢測試劑

埃博拉病毒檢測試劑

鼠疫檢測試劑

鉤端螺旋體檢測試劑

黃熱病檢測試劑

寨卡病毒檢測試劑

軍團菌檢測試劑

想了解更多的產品及服務請掃描下方二維碼：

【公司名稱】 廣州健侖生物科技有限公司

【公司號碼】:020-8257 4011  

【咨詢手機】：1-3-8-0-2-5-2-5-2-7-8  楊永漢

【騰訊QQ】7 1 2 9 8 2 2 2 9 

【公司地址】廣州清華科技園創新基地番禺石樓鎮創啟路63號二期2幢101-103室

 生活史：

  卡氏肺孢子蟲在人和動物肺組織內的發育過程已基本清楚，但在宿主體外的發育階段尚未*明了。一般認為本蟲的包囊經空氣傳播而進入肺內。動物實驗證實其在肺泡內發育的階段，有滋養體、囊前期和包囊期三個時期。滋養體從包囊逸出經二分裂和內出芽和接合sheng殖等進行繁殖。滋養體細胞膜漸增厚形成囊壁，進入囊前期；隨后囊內核進行分裂，每個核圍以一團胞質，形成形成囊內小體。發育成熟的包囊含8個囊內小體，以后脫囊而出形成滋養體。 1984年吉用幸雄等用電子顯微鏡觀察囊前期早期發育的構造，內含有聯會復合體。當聯會復合體消失后進行兩次連續的減數分裂和一次有絲分裂，形成8個囊內小體。