西班牙Certest滅活的鮑氏志賀氏菌抗原（天然提取物）

廣州健侖生物科技有限公司

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西班牙Certest滅活的鮑氏志賀氏菌抗原（天然提取物）

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目前，美國羅格斯大學(xué)副教授Ki-Bum Lee開發(fā)的一項技術(shù)，可以克服利用干細(xì)胞完整治療潛力的一個關(guān)鍵障礙。
致力于再生細(xì)胞并培養(yǎng)新組織來治療衰竭性損傷和疾病(如帕金森病、心臟病和脊髓損傷)的研究人員，所面臨的一個主要挑戰(zhàn)是，創(chuàng)建一種簡單、有效和無毒性的方法，來控制到特定細(xì)胞譜系的分化。Lee及其羅格斯大學(xué)、日本京都大學(xué)的同事們，發(fā)明了一種平臺，他們稱之為NanoScript，對于基因表達(dá)領(lǐng)域的研究人員來說，這是一個重要的突破。基因表達(dá)是指細(xì)胞在生命過程中，把儲存在DNA順序中遺傳信息經(jīng)過轉(zhuǎn)錄和翻譯，轉(zhuǎn)變成具有生物活性的蛋白質(zhì)分子，對于通過干細(xì)胞治療的組織發(fā)育過程是很重要的。
干細(xì)胞具有很大的潛力應(yīng)用于各種醫(yī)學(xué)治療，因為它們能夠培養(yǎng)整個身體的組織。在許多組織中，干細(xì)胞作為一種內(nèi)部修復(fù)系統(tǒng)，具有幾乎無限分裂和補充其他細(xì)胞的能力。
轉(zhuǎn)錄因子(TF)蛋白質(zhì)是基因表達(dá)的主要調(diào)控因子。TF蛋白在調(diào)控干細(xì)胞分化過程中發(fā)揮重要的作用。雖然有些人試圖制造行使天然轉(zhuǎn)錄因子功能的合成分子，但NanoScript是*個能夠與內(nèi)源DNA相互作用的納米材料TF蛋白質(zhì)。Lee關(guān)于NanoScript的這項研究，發(fā)表在zui近的美國化學(xué)學(xué)會期刊《ACS Nano》。該研究是由美國國立衛(wèi)生研究院(NIH)資助支持。
Lee帶領(lǐng)羅格斯大學(xué)的一個研究小組，主要集中開發(fā)和整合納米技術(shù)與化學(xué)生物學(xué)，來調(diào)控癌癥和干細(xì)胞中的信號通路。他指出：“我們的動機是，開發(fā)一種非常強大的、高效的納米粒子為基礎(chǔ)的平臺，能夠調(diào)節(jié)基因表達(dá)，zui終調(diào)節(jié)干細(xì)胞的分化。因為NanoScript是TF蛋白的一個功能性復(fù)制品和一個可調(diào)諧的基因調(diào)控平臺，它有巨大的潛力做到這一點。現(xiàn)在，干細(xì)胞生物學(xué)領(lǐng)域有另外一種平臺來調(diào)控分化，而納米技術(shù)領(lǐng)域*證明，我們可以在轉(zhuǎn)錄水平上調(diào)控基因表達(dá)。”
NanoScript是由網(wǎng)絡(luò)共享功能肽和小分子(稱為合成轉(zhuǎn)錄因子)構(gòu)建而成，模擬單個TF結(jié)構(gòu)域，映射到金納米粒子上。
本文共同作者、羅格斯大學(xué)化學(xué)研究生Sahishnu Pa指出：“NanoScript定位在細(xì)胞核內(nèi)，可高達(dá)30倍地啟動一個報告質(zhì)粒的轉(zhuǎn)錄。NanoScript可以一種非病毒的方式，有效地在內(nèi)源性DNA上轉(zhuǎn)錄靶基因。”
Lee說，他的研究的下一步是，探討利用NanoScript后，金納米粒子上發(fā)生了什么情況，以確保沒有毒害作用產(chǎn)生，并確保NanoScript長時間的有效性。

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想了解更多的產(chǎn)品及服務(wù)請掃描下方二維碼：

【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【騰訊  】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

Currently, a patented technology developed by Ki-Bum Lee, an associate professor at Rutgers University, can overcome one of the key barriers to harnessing the full therapeutic potential of stem cells.
A major challenge for researchers working on regenerating cells and developing new tissue to treat failing lesions and diseases such as Parkinson's disease, heart disease, and spinal cord injury is creating a simple, effective, and non-toxic approach , To control the differentiation of specific cell lineages. Lee and his colleagues at Rutgers University and Kyoto University in Japan invented a platform that they call NanoScript, an important breakthrough for researchers in the field of gene expression. Gene expression refers to the cells in the life process, stored in the DNA sequence of genetic information through transcription and translation, into a biological activity of protein molecules, through the stem cell treatment of tissue development is very important.
Stem cells have great potential for use in a variety of medical treatments because they are capable of developing tissue throughout the body. In many tissues, stem cells act as an internal repair system that has the ability to divide and replenish other cells almost indefiniy.
Transcription factor (TF) proteins are the major regulatory elements of gene expression. TF protein plays an important role in the regulation of stem cell differentiation. Although some people try to make synthetic molecules that perform the function of natural transcription factors, NanoScript is the first TF protein of nanomaterials that interacts with endogenous DNA. Lee's research on NanoScript was published in the recent ACS Nano Journal. The study was funded by the National Institutes of Health (NIH).
Lee led a research group at Rutgers, which focused on developing and integrating nanotechnology and chemical biology to regulate signaling pathways in cancer and stem cells. "Our motivation is to develop a very powerful and efficient nanoparticle-based platform that regulates gene expression and eventually regulates stem cell differentiation, because NanoScript is a functional copy of the TF protein and a Tuned gene regulation platform, which has great potential to do this.Now there is another platform in stem cell biology to regulate differentiation, and for the first time in the field of nanotechnology, that we can regulate gene expression at the transcriptional level. "
NanoScript is a network of shared functional peptides and small molecules (called synthetic transcription factors) constructed to simulate a single TF domain, mapped to gold nanoparticles.
Co-author Sahishnu Pa, a graduate student in chemistry at the University of Rutgers, said: "NanoScript, which is located in the nucleus, can initiate up to 30-fold transcription of a reporter plasmid. NanoScript works efficiently on endogenous DNA in a non-viral fashion Transcription target genes. "
Lee said the next step in his research is to explore what happens to gold nanoparticles after using NanoScript to ensure no toxic effects and to ensure the long-term effectiveness of NanoScript.