英文名稱	Anti-Acylglycerol Kinase/FITC
中文名稱	FITC標記的甘油酯激酶線粒體抗體
別名	mitochondrial; Acylglycerol kinase; Acylglycerol kinase mitochondrial; agk; AGK_HUMAN; hAGK; HsMuLK; MuLK; Multi substrate lipid kinase; Multi-substrate lipid kinase; Multiple substrate lipid kinase.
說明書	100ul
研究領域	腫瘤細胞生物信號轉導激酶和磷酸酶腫瘤細胞生物標志物線粒體
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
產品應用	IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	47kDa
細胞定位	細胞膜線粒體
性狀	Lyophilized or Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Acylglycerol Kinase
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹	background: The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. Function: Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth. Subcellular Location: Mitochondrion membrane. Tissue Specificity: Highly expressed in muscle, heart, kidney and brain. DISEASE: Defects in AGK are the cause of mitochondrial DNA depletion syndrome type 10 (MTDPS10) [MIM:212350]. An autosomal recessive mitochondrial disorder characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, and lactic acidosis. Mental development is normal, but affected individuals may die early from cardiomyopathy. Defects in AGK are the cause of cataract, congenital, autosomal recessive type 5 (CATC5) [MIM:614691]. CATC5 consists of an opacification of the crystalline lens of the eye becoming evident at birth. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.